Valget af kraftigt virkende medicin i smertebehandling er en opvejning mellem bivirkninger og virkning samt hvor stærke smerterne er.forslag til behandlingsalgoritme for perorale behandlinger af neuropatiske smerter startdoser og hastighed for optitrering af de enkelte præparater findes sidst i instruksen.Hvis TCA har været forsøgt i fuld dosis
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